Hyaluronic Acid and Periodontal Disease: A Breakthrough in Gum Healing

What Is Hyaluronic Acid?

Hyaluronic acid (HA) is a naturally occurring molecule found in the human body — especially abundant in the skin, eyes, joints, and connective tissue. It’s known for its remarkable ability to retain water, promote tissue repair, and reduce inflammation. But what’s less commonly discussed is its powerful role in oral health, particularly when it comes to periodontal disease.

We use it in our toothpaste

It makes our toothpaste gooey and tacky which helps users actually apply it. Unlike a lot of natural toothpaste and powders that just dissolve and pool up in the bottom of your mouth. 

Periodontal Disease: A Quick Overview

Periodontal disease is a chronic inflammatory condition that affects the gums and bone structures that support your teeth. It begins as gingivitis (mild inflammation) and, if left untreated, can develop into periodontitis — a more severe condition marked by gum recession, bone loss, and even tooth loss.

Common signs include:

• Red, swollen, or bleeding gums

• Gum recession

• Persistent bad breath

• Tooth sensitivity

• Loose or shifting teeth

The root cause? A disrupted oral microbiome and chronic inflammation that damages the soft tissues and bone. That’s where hyaluronic acid comes in.

Correct your oral microbiome with our xylitol mints

Hyaluronic Acid for Periodontal Health

Hyaluronic acid is already used in dermatology and joint care for its regenerative and hydrating properties, but it has also been studied for its direct effects on gum tissues.

📊 Key Findings from Research:

• A systematic review published in Journal of Clinical Periodontology found that topical application of HA significantly improved periodontal outcomes, reducing bleeding, pocket depth, and inflammation compared to controls (Pilloni et al., 2019).

• Another clinical study showed that using hyaluronic acid gel post-scaling and root planing led to better tissue regeneration and lower inflammation markers (Jentsch et al., 2003).

• Hyaluronic acid has been shown to modulate pro-inflammatory cytokines, helping to reduce tissue destruction during periodontitis (Gontiya & Galgali, 2012).

In short, HA doesn’t just hydrate. It plays a profound role in healing oral tissues, making it one of the most promising active ingredients in a periodontal toothpaste.

Why Most Toothpastes Miss the Mark

Traditional commercial toothpastes focus on plaque removal and fluoride-based remineralization, but they often ignore the gum health component. Many contain harsh detergents (like SLS), synthetic preservatives, artificial dyes, and even microplastics — all of which can irritate the gums and further damage the oral microbiome.

Even "natural" brands often fall short by excluding essential healing ingredients or using ineffective doses. When battling periodontal disease, you need a formula that goes far beyond surface-level cleaning. Glycerine is a common ingredient in classic fluoride and natural formulas alike. Glycerine is an 

Why TranscenDental Includes Hyaluronic Acid — And So Much More

At TranscenDental, we didn’t stop at including hyaluronic acid — we built our entire formula around gum regeneration, oral microbiome support, and tooth remineralization, making it the best toothpaste for periodontal disease.

🔬 Our Periodontal Power Formula Includes:

• 15% Hydroxyapatite – A clinically proven alternative to fluoride that rebuilds enamel while being completely safe to swallow.

• Buffered Vitamin C (Calcium Ascorbate) – For collagen production and antioxidant protection.

• Methylated B Vitamins – To fuel cellular regeneration at the gum line.

• Xylitol – Starves harmful bacteria while supporting beneficial flora.

• Black Cumin Seed Oil, Gotu Kola, Yarrow & Rosemary – Adaptogenic botanicals with strong anti-inflammatory and wound-healing effects.

Each ingredient works synergistically to address the underlying causes of gum disease — not just the symptoms.

How Hyaluronic Acid Improves the Experience

Most natural toothpastes feel gritty or dry — and conventional pastes leave a filmy, chemical taste. But hyaluronic acid transforms the texture of the formula, making it smooth, moisturizing, and soothing to the gums.

You’ll feel the difference immediately:

• No burning sensation

• No synthetic aftertaste

• A hydrated, clean-feeling mouth

Safe, Swallowable, and Science-Backed

We believe you shouldn't need a poison control warning on your toothpaste. Every ingredient in our formula is not only safe to swallow — it’s actively beneficial to your body. That includes hyaluronic acid, which is naturally found in your tissues and well-tolerated even at high doses.

Unlike many nano-particle or chemical-laden formulations, ours is crafted with organic and food-grade ingredients, using only stainless steel equipment to avoid contamination with microplastics or industrial residues.

Final Thoughts: The Best Periodontal Toothpaste Starts With Healing

If you’re battling gum disease, don’t settle for a toothpaste that just scrubs and foams. Choose one that:

• Rebuilds your enamel (without fluoride)

• Nourishes and repairs your gums

• Respects and supports your oral microbiome

That’s why TranscenDental is quickly becoming known as the best toothpaste for periodontal disease — because it works with your body, not against it.

👉 Try TranscenDental Mouth Paste Now and experience the difference hyaluronic acid can make.

Keywords Used: periodontal toothpaste, best toothpaste for periodontal disease, xylitol toothpaste, hydroxyapatite toothpaste, natural whitening toothpaste