The Periodontal Powerhouse: Hyaluronic Acid, Buffered Vitamin C, and Methylated B Vitamins

When we set out to develop the best periodontal toothpaste available, we didn’t just want a gentle cleaner. We wanted a formula that actively helped regenerate inflamed, damaged, and aging gum tissue. Our solution? A powerhouse trio: hyaluronic acid, buffered vitamin C (calcium ascorbate), and a full spectrum of methylated B vitamins.

If you're dealing with periodontal disease — or trying to avoid it — this post breaks down how and why this combination of ingredients creates a radical leap forward in oral care, especially when paired with xylitol toothpaste and hydroxyapatite toothpaste bases.

Or you can skip all this info and get right to the gum healing toothpaste we make. 

What Is Periodontal Disease — And Why Is It So Hard to Heal?

Periodontal disease isn't just about plaque or bad brushing habits. It's a chronic inflammatory condition that causes progressive loss of connective tissue and bone around the teeth. Once you’re in deep — bleeding gums, bone loss, receding tissue — reversing the process is incredibly difficult. That’s because traditional treatments rarely address the underlying nutritional and regenerative needs of the tissue.

We looked at what the gums actually need to heal, not just avoid further damage. Here's what we found.

https://www.mayoclinic.org/diseases-conditions/periodontitis/symptoms-causes/syc-20354473

https://www.nidcr.nih.gov/health-info/gum-disease

Hyaluronic Acid: The Skin-Level Hydrator for Your Gums

Most people know hyaluronic acid (HA) for its benefits in skincare — plumping, hydrating, and regenerating aging tissue. But few realize your gingival tissues also contain HA and rely on it for structure, water retention, and cell signaling.

What HA Does in the Mouth:

• Moisturizes and hydrates oral tissues, preventing dry mouth and cracking

• Speeds wound healing, especially in inflamed or ulcerated gums

• Reduces inflammation by modulating immune responses

• Supports collagen synthesis and gum volume

A 2016 study published in Clinical Oral Investigations showed HA applications reduced bleeding and improved healing after deep cleanings in periodontitis patients. It’s essentially like giving your gums a hydration IV.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3690787/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8773125/

Buffered Vitamin C (Calcium Ascorbate): The Tissue Repair King

Vitamin C is crucial for collagen synthesis — no surprise that scurvy (vitamin C deficiency) famously leads to bleeding gums and tooth loss. But we go a step further by using buffered vitamin C (in the form of calcium ascorbate), which is gentler on sensitive oral tissues and less acidic than ascorbic acid.

Why Calcium Ascorbate Works:

• Promotes collagen formation for strong, elastic gums

• Reduces bleeding and inflammation

• Acts as an antioxidant to neutralize ROS damage in gum pockets

• Supports immune function right at the tissue site

Paired with HA, it doesn’t just soothe — it builds. And it doesn’t sting the way raw ascorbic acid often does.

The Best Periodontal Toothpaste has Methylated B Vitamins

You are going to want to try the only with with ALL these benefits, here. 

Inflamed or receding gums aren’t just structural issues — they’re metabolic ones. Your oral tissue is constantly turning over cells, and that process requires methylation and active cofactors from B-complex vitamins.

We use the methylated versions of:

• B9 (Methylfolate)

• B12 (Methylcobalamin)

• B6 (Pyridoxal-5-Phosphate)

Why methylated? Because many people have MTHFR polymorphisms and cannot efficiently activate standard B vitamins.

Benefits:

• Drives cell turnover and tissue repair

• Reduces homocysteine and inflammation

• Supports microcirculation in the gums

• Essential for epithelial regeneration

This trio is especially critical when you’re recovering from gum trauma, gingivitis, or surgery.

The Role of Vitamin B Complex in Periodontal Disease: A Systematic Review Examining Supplementation Outcomes, Age Differences in Children and Adults, and Aesthetic Changes

Effects of vitamin-B complex supplementation on periodontal wound healing

Xylitol & Hydroxyapatite Toothpaste Synergy

You’ll notice this healing blend is embedded in a base of xylitol toothpaste and 15% hydroxyapatite toothpaste. That’s intentional.

• Xylitol inhibits pathogenic bacteria while feeding beneficial flora, which is critical for reducing the bacterial load driving inflammation.

• Hydroxyapatite repairs enamel and protects exposed roots — often an issue in periodontal disease.

Together, they create a safe-to-swallow, non-toxic oral therapy that heals at every level: microbial, structural, and biochemical.

Get your toothpaste here and see the power for yourself. Stop those gums from bleeding.

Periodontal Toothpaste: Why we are the industry best

If you’ve struggled with bleeding gums, pockets, or receding tissue, you’ve likely been told to floss harder and "watch it." But what your mouth needs is fuel — not just friction.

By using a toothpaste that combines:

• Hyaluronic acid for hydration and healing

• Buffered vitamin C for tissue strength

• Methylated B vitamins for metabolic regeneration

• Xylitol and Hydroxyapatite for biome and enamel support

…you’re not just brushing. You’re restoring.

This is what we believe the best periodontal toothpaste should do — and we made it.